System32 is an infamous virus known to infect Windows computers. The earliest confirmed sightings of System32 are from the Windows 2000 era, though the virus and/or its predecessors might be older. Although computer health specialists have been warning of the infection since at least the early 2000s, its existence and henceforth its danger did not enter into the popular conscious until in late 2006, when Channel 4 began dispatching medical experts across the internet to warn of the virus' danger.

Unfortunately, System32 is able to install a defense mechanism against deletion immediately after infects a computer, making treatment considerably difficult. Thankfully, Channel 4 users were able to devise counter-measures capable of bypassing even the most advanced defense systems System32 is capable of programming.